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A health care company with global reach.
A product pipeline filled to the brim. A team committed to
scientific advancement. Think what's possible.
A global healthcare leader, Novartis
has one of the most exciting product pipelines in the industry
today. A pipeline of innovative medicines brought to life by
diverse, talented, performance driven people. All of which makes us
the most rewarding employer in our field.
Computational ADME Scientist (BS/MS)
58051BR
NIBR
NIBR
USA
United States - Massachusetts
USA Novartis Institutes for BioMedical Research, Inc., Cambridge, MA
Metabolism & Pharmacokinetics (MAP)
Full Time
Permanent
The Metabolism and Pharmacokinetics group at Novartis Institutes for Biomedical Research (NIBR) is looking for a highly qualified M.Sc. level scientist in the area of computational ADME. The successful candidate will have responsibility for computational analysis and modeling of pharmacokinetic data using a variety of approaches. In addition, a successful candidate will be expected to interact with drug metabolism scientists in planning and conducting appropriate modeling efforts in support of investigations into program-specific ADME issues.
Candidates possessing an M.Sc. in Computational Chemistry or a closely related discipline with 5+ years of experience in in silico modeling in the drug metabolism and pharmacokinetics field within a pharmaceutical or biotechnology company. An in-depth understanding of all aspects of computational modeling within DMPK with special emphasis on descriptor calculation software, multivariate modeling approaches and application in the drug discovery setting is required. A successful candidate must be able to plan, conduct and interpret ADME modeling investigations in support of drug discovery efforts. A good working knowledge of drug metabolism and pharmacokinetics is required, with strong competencies in computational modeling via PLS, RF, neural networks or similar, as well as descriptor calculation software. Experience with pharmacokinetic modeling software (e.g. WinNonLin), programming language (e.g. C++, Java), and Linux operating systems is highly desired. A successful candidate will need excellent interpersonal skills, particularly oral and written communication skills.
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