Research Associate II, Cellular Sciences: Alexion Pharmaceuticals,Inc.

Research Associate II, Cellular Sciences

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About Us

Alexion is a global biopharmaceutical company that combines groundbreaking science with a steadfast commitment to meeting the needs of patients living with severe, life-threatening and often ultra-rare diseases. Alexion scientists are among the first in the world to unlock the therapeutic potential of inhibiting terminal complement, a group of proteins that play an important role in the body's immune response and can destroy healthy tissue in certain patients.

Alexion discovered and developed Soliris® (eculizumab), a first-in-class terminal complement inhibitor approved in the United States, European Union, Canada and Australia as a treatment for patients with paroxysmal nocturnal hemoglobinuria (PNH). Alexion is working urgently to investigate Soliris and additional biopharmaceuticals as treatments for patients with other rare and severe diseases, including cancer.

Summary

Responsiblities:

• Work on projects aimed at the discovery and development of potential new therapeutic targets

• Perform cell-based in vitro assays to characterize the performance of candidate biologic molecules

• Evaluate the immunomodulatory and/or anti-tumor activity of potential therapeutics in cell-based assays in vitro.

• Assist in the performance of preclinical experiments in vivo.

• Maintain short and long-term mammalian cell cultures.

• Present and summarize scientific results in oral presentations and reports.

Visa Sponsorship Not Available for this Position

Requirements

• Qualified candidates must have a BA/BS with 2-3 years of relevant work experience in the areas of Immunology or Cell Biology.

• Proficiency in aseptic technique (mammalian cell culture), hybridoma generation, cell-based assays (human and/or mouse lymphocyte isolation, proliferation, cytokine release, intracellular cytokines, flow cytometry, etc.) and analytical assays (ELISA, antibody binding assays) is desirable.

• Experience in small animal in vivo models is desired. The candidate will work closely with other members of the Cellular Sciences department to perform target validation and to characterize the potential functional activity of candidate therapeutic antibodies and proteins.

• The individual should be highly motivated, demonstrate superior organizational skills, and once trained, have the flexibility to manage multiple projects simultaneously and relatively independently.
• Good interpersonal skills will be particularly important, as this individual will often work as part of a cross-functional team to meet departmental goals and timelines.

About Alexion Pharmaceuticals

Alexion Pharmaceuticals, Inc. is a biopharmaceutical company working to develop and deliver life-changing drug therapies for patients with serious and life-threatening medical conditions. Employing more than 500 people worldwide, Alexion is engaged in the discovery, development and commercialization of therapeutic products aimed at treating patients with a wide array of severe disease states, including hematologic and kidney diseases, transplant, cancer, and autoimmune disorders. Soliris^(R) (eculizumab) is Alexion's first marketed product for patients with paroxysmal noctural hemoglobinuria (PNH) a rare, debilitating and life-threatening blood disorder defined by the destruction of red blood cells, or hemolysis. Soliris is approved in the U.S. and Europe in 2007, and Canada and Australia in 2009. Alexion is evaluating other potential indications for Soliris as well as other formulations of eculizumab for additional clinical indications, and is pursuing development of other antibody product candidates in early stages of development.

Alexion offers a highly competitive package of base and incentive compensation, group healthcare coverage, tuition reimbursement, relocation assistance, and a 401(K) plan.

Alexion is an Equal Opportunity/Affirmative Action Employer.

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